The cardboard box study: understanding collaborative data management in the connected home

The home is a site marked by the increasing collection and use of personal data, whether online or from connected devices. This trend is accompanied by new data protection regulation and the development of privacy enhancing technologies (PETs) that seek to enable individual control over the processing of personal data. However, a great deal of the data generated within the connected home is interpersonal in nature and cannot therefore be attributed to an individual. The cardboard box study adapts the technology probe approach to explore with potential end users the salience of a PET called the Databox and to understand the challenge of collaborative rather than individual data management in the home. The cardboard box study was designed as an ideation card game and conducted with 22 households distributed around the UK, providing us with 38 participants. Demographically, our participants were of varying ages and had a variety of occupational backgrounds and differing household situations. The study makes it perspicuous that privacy is not a ubiquitous concern within the home as a great deal of data is shared by default of people living together; that when privacy is occasioned it performs a distinct social function that is concerned with human security and the safety and integrity of people rather than devices and data; and that current ‘interdependent privacy’ solutions that seek to support collaborative data management are not well aligned with the ways access control is negotiated and managed within the home

Modification and preservation of environmental signals in speleothems

Speleothems are primarily studied in order to generate archives of climatic change and results have led to significant advances in identifying and dating major shifts in the climate system. However, the climatological meaning of many speleothem records cannot be interpreted unequivocally; this is particularly so for more subtle shifts and shorter time periods, but the use of multiple proxies and improving understanding of formation mechanisms offers a clear way forward. An explicit description of speleothem records as time series draws attention to the nature and importance of the signal filtering processes by which the weather, the seasons and longer-term climatic and other environmental fluctuations become encoded in speleothems. We distinguish five sources of variation that influence speleothem geochemistry: atmospheric, vegetation/soil, karstic aquifer, primary speleothem crystal growth and secondary alteration and give specific examples of their influence. The direct role of climate diminishes progressively through these five factors. \ud \ud We identify and review a number of processes identified in recent and current work that bear significantly on the conventional interpretation of speleothem records, for example: \ud \ud 1) speleothem geochemistry can vary seasonally and hence a research need is to establish the proportion of growth attributable to different seasons and whether this varies over time. \ud \ud 2) whereas there has traditionally been a focus on monthly mean Ã�´18O data of atmospheric moisture, current work emphasizes the importance of understanding the synoptic processes that lead to characteristic isotope signals, since changing relative abundance of different weather types might 1Corresponding author, fax +44(0)1214145528, E-mail: [email protected] control their variation on the longer-term. \ud \ud 3) the ecosystem and soil zone overlying the cave fundamentally imprint the carbon and trace element signals and can show characteristic variations with time. \ud \ud 4) new modelling on aquifer plumbing allows quantification of the effects of aquifer mixing. \ud \ud 5) recent work has emphasized the importance and seasonal variability of CO2-degassing leading to calcite precipitation upflow of a depositional site on carbon isotope and trace element composition of speleothems. \ud \ud 6) Although much is known about the chemical partitioning between water and stalagmites, variability in relation to crystal growth mechanisms and kinetics is a research frontier. \ud \ud 7) Aragonite is susceptible to conversion to calcite with major loss of chemical information, but the controls on the rate of this process are obscure. \ud \ud Analytical factors are critical to generate high-resolution speleothem records. A variety of methods of trace element analysis are available, but standardization is a common problem with the most rapid methods. New stable isotope data on Irish stalagmite CC3 compares rapid laser-ablation techniques with the conventional analysis of micromilled powders and ion microprobe methods. A high degree of comparability between techniques for Ã�´18O is found on the mm-cm scale, but a previously described high-amplitude oxygen isotope excursion around 8.3 ka is identified as an analytical artefact related to fractionation of the laser-analysis associated with sample cracking. High-frequency variability of not less than 0.5o/oo may be an inherent feature of speleothem Ã�´18O records

Space assets and technology for bushfire management

The financial, emotional, and ecological impacts of bushfires can be devastating. This report was prepared by the participants of the Southern Hemisphere Space Studies Program 2021 in response to the topic: “How space assets and technologies can be applied to better predict and mitigate bushfires and their impacts.” To effectively reach the diverse set of stakeholders impacted by bushfires, Communication was identified as a key enabler central to any examination of the topic. The three pillars “predict”, “mitigate” and “communicate” were identified to frame the task at hand. Combining the diverse skills and experience of the class participants with the interdisciplinary knowledge gained from the seminars, distinguished lectures, and workshops during the SHSSP21 program, conducted a literature review With specific reference to the 2019-20 Australian fire season, we looked at the current state of the art, key challenges, and how bushfires can be better predicted and mitigated in the future. Comparing this to the future desired state, we identified gaps for each of the three domains, and worked across teams to reach consensus on a list of recommendations. Several of these recommendations were derived independently by two or more of the three groups, highlighting the importance of a holistic and collaborative approach. The report details a number of recommendations arising from this Where applicable, we also aligned our discussion with the experience and lessons from other countries and agencies to consider,learn from and respond to the international context, as others develop systems using space technology to tackle similar wildfire issues

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Organic acid fluorescence: applications to speleothem palaeoenvironmental reconstruction

Recent advances in fluorescence spectrophotometry permit the non-destructive analysis of speleothems (secondary carbonate cave deposits) with a view to palaeoenvironmental reconstruction. The fluorescence of speleothems is derived from organic acids that have been carried by groundwater from the overlying soil, and coprecipitated with the speleothem calcite. Organic acids are formed as one of the many products of humification and their chemical structures are such that they are particularly suitable for analysis by fluorescence spectrophotometry. Numerous studies have been carried out that have demonstrated the structure and hence the fluorescence properties of organic acids to be influenced by many factors, including extraction method, concentration, source, pH, metal and inorganic ion complexing and, most importantly in the case of speleothems, soil type and climate and vegetation change. On the basis of this, recent investigations carried out on contemporary, historical and Quaternary samples have shown it to be possible to obtain palaeoenvironmental information from the fluorescence properties of organic acids in speleothems

Towards a master narrative for trust in autonomous systems:Trust as a distributed concern

In this paper we present findings of research into Trust, specifically within the context of Autonomous Systems. The research is based upon an exploratory workshop attended by domain experts from academia and industry. The aim of the work is to synthesise interdisciplinary and high-level understandings of pertinent issues into a singular and cohesive Master Narrative relating to Trust an Autonomous Systems. The inquiry constructs a Master Narrative that casts Trust as a notion that is necessarily constructed by complex relationships, disciplinary lenses, and multiple concurrent stakeholders. We term this ‘Trust as a Distributed Concern’. The paper describes the research and analysis which underpins the concept of Trust as a Distributed Concern and discusses how the concept may be operationalised in research and innovation contexts

Late Quaternary speleothem pollen in the British isles

As with many terrestrial areas, the British Quaternary sequence is characterised by incomplete, fragmentary records, whose correlation is based on stratigraphic or biostratigraphic techniques due to the lack of radiometric ages beyond the similar to 40 kyr limit of C-14 dating. Speleothems (secondary cave calcite deposits) offer a significant advantage over many sources of palaeoenvironmental information; they can be dated to a high precision and accuracy by uranium-thorium (U-238-Th-230) thermal ionisation and inductively coupled plasma (ICP) mass spectrometry in the time period back to 500 kyr. They may also contain sufficient well-preserved pollen representative of contemporary vegetation above the cave to allow palaeoenvironmental reconstruction. This study adopts the novel approach of combining pollen and thermal ionisation mass spectrometric (TIMS) U-Th dating of British speleothems to produce well-constrained palaeoenvironmental records. We report for the first time precisely dated records of pollen assemblages from speleothems suggesting the presence of thermophilous arboreal species in phases previously considered to have been consistently cool or cold and devoid of trees. Copyright (C) 2007 John Wiley &amp; Sons, Ltd.</p